Prisma Health will soon begin a $350 million expansion of Greer Memorial Hospital that will double the number of patient beds and expand outpatient care through the development of a medical park, the health system announced July 22.
Site preparation for the project is expected to begin this fall.
According to Prisma, the project includes:
- New pediatric and cardiovascular specialty units
- Expansions will roughly double the size of the emergency department with expanded space for labor and delivery, intensive care and surgical units
- Additional primary and specialty care offices in the new building, including a new ear, nose and throat practice and expanded urology, cardiology, pulmonology and neurology practices
- Additional pediatric specialty practices

The project represents Prisma Health’s largest investment in expanding an Upstate medical campus in nearly 20 years.
The expansion will increase Greer Memorial’s licensed bed count to 175, a 93-bed jump. The state Department of Public Health approved Prisma’s Certificate of Need application in June.
Construction on the $250 million hospital expansion and renovation will be done in phases. It’s expected to be completed in early 2028. It will include construction of a three-story 110,000-square-foot tower adjacent to the existing hospital.

Construction on the $100 million medical office building will begin in early 2026 and is expected to be ready for its first patient by mid-2027. The medical park will be built on South Buncombe Road directly across from Greer Memorial. The project will include a three-story, 100,000-square-foot outpatient office with easy-access parking.